Program
Approximate slot length:
invited speakers: 35 min (25+10)
young scientists: 25 min (15+10)
Monday, 23 November 2020
| 09:45 | Welcome Rainer Engers (Düsseldorf, Germany) on behalf of the AEK Lisa Wiesmüller (Ulm, Germany) |
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| Session 1: Replication stress in
the hematopoietic system (Chair: Lisa Wiesmüller, Ulm, Germany) |
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| 10:00 – 10.35 | Michael Milyavsky (Tel Aviv, Israel): Regulation of DNA damage response in normal and malignant hematopoietic stem cells |
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| 10:35 – 11.00 | Susanne Lux (Heidelberg, Germany - PhD): Genetic rescue of Fanca-/- HSPCs with EVI-1 overexpression suggests a mechanistic link with DNA damage response |
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| Session 2: Non-canonical roles
of p53 and MDM2 (Chair: Vanesa Gottifredi, Buenos Aires, Argentina) |
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| 11:00 – 11:35 | Lisa Wiesmüller (Ulm, Germany): The tip of an iceberg: replication-associated functions of the tumor suppressor p53 and Stephanie Biber (Ulm, Germany - PhD): Multiple biochemical properties of the p53 molecule contribute to activation of POLi -dependent DNA damage tolerance |
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| 11:35 – 12:00 | Michaela Ihle (Ulm, Germany): Impact of the interplay between stemness features, p53 and POLi on replication pathway choices |
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| 12:00 – 12:25 | Matthias Dobbelstein (Göttingen, Germany): The interplay of p53 and Mdm2 in the context of DNA replication |
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| 12:25 – 13:00 | Celeste Giansanti & Valentina Manzini
(Göttingen,
Germany): MDM2 promotes restart of reversed replication forks by interacting with PARP1 |
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| 13:00 – 14:00 | Lunch | |
| Session 3: Crosstalk between DNA
repair, replication and transcription (Chair: Lisa Wiesmüller, Ulm, Germany) |
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| 14:00 – 14:35 | Alex Sartori (Zürich, Switzerland): Distinct roles of CtIP in repairing DNA double strand breaks and limiting replication stress |
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| 14:35 – 15:10 | Joanna Morris (Birmingham, United Kingdom): Chromatin ubiquitination supports FEN1-WRN alleviation of replication stress |
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| 15:10 – 15:35 | Franziska Gehringer (Ulm, Germany - PhD): FOXO3 expression is essential for the survival of Burkitt Lymphoma |
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| 15:35 – 16:00 | Sonja Krausert (Heidelberg, Germany): Targeting replication stress in pediatric brain tumors |
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| 16:00 – 16:25 | Isabelle Röschert (Würzburg, Germany): Aurora-A suppresses transcription-replication conflicts in MYCN-driven neuroblastoma |
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| 16:25 – 17:00 | Philippe Pasero (Montpellier, France): Causes and consequences of endogenous replication stress |
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Tuesday, 24 November 2020
| Session 4: Safeguarding the fork
and adaptation (Chair: Matthias Dobbelstein, Göttingen, Germany) |
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| 09:00 – 09:35 | Helmut Pospiech (Jena, Germany): Fifty shades of replication stress |
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| 09.35 – 10.00 | Gleice Borges (Jena, Germany): Role of RAD18 in replication stress adaptation and tissue homeostasis |
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| 10:00 – 10:35 | Claus Sørensen (Copenhagen, Denmark): Pathways ensuring faultless cell proliferation: Uncovering new tumor suppressors |
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| 10.35 – 11.00 | Sandra Classen (Hamburg,
Germany): The adaptive resistome in triple-negative breast cancer: functional targeting in patient-derived organoids and cell lines |
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| 11.00 – 11.25 | Akram Hamidi (Essen, Germany - PhD): Analysis of growth and radiation sensitivity of HIF-1A deficient cultured murine hepatocytes |
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| Session 5: Underreplicated DNA (Chair: Claus Sørensen, Copenhagen, Denmark) |
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| 11.25 – 12.00 | Vanesa Gottifredi (Buenos Aires, Argentina): Chromosome instability: an enemy or an ally against cancer? |
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| 12.00 – 12.25 | Nicolás Calzetta (Buenos Aires, Argentina): Molecular bases of the genomic instability triggered by incomplete MIDAS in Chk1 deficient backgrounds |
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| 12.25 – 12.50 | Audrey Lumeau (Toulouse, France): A new role for cytidine deaminase in the control of DNA replication and genome stability in pancreatic cancer cells |
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| 12.50 – 13.15 | Kanstantsin Siniuk (Jena, Germany -
PhD): Poly(ADP-ribose) regulation of Chk1 in cell cycle control and cancer therapy |
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| 13:15 – 14:00 | Lunch | |
| Session 6: Helicases (Chair: Helmut Pospiech, Jena, Germany) |
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| 14:00 – 14:35 | Francesca Pisani (Naples, Italy): Exploring the role of DDX11 and FANCJ DNA helicases in counteracting replication stress |
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| 14.35 – 15.00 | Sara Egea-Rodriguez (Essen, Germany): Role of DNA helicases in survival and progression of cancer patients – a bioinformatics analysis |
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| Session 7: Strategies to
overcome resistance (Chair: Helmut Pospiech, Jena, Germany) |
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| 15.00 – 15.25 | Julia Mann (Düsseldorf, Germany): Targeting mechanisms of the DNA damage response to overcome cisplatin resistance |
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| 15.25 – 15.50 | Natalie Bublitz (Berlin, Germany): Modeling vulnerability of KRAS and BRAF mutant colorectal cancer towards interference with DNA damage response |
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| 15.50 – 16.15 | Linda van Bijsterveldt (Oxford, United Kingdom): Regulation of E2F target gene expression in the replication stress response |
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| 16.15 – 16.50 | Eric J Brown (Philadelphia, USA): Genomic potholes in the road to replication |
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| 16:50 | Award Ceremony & Farewell | |