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Approximate slot length:
invited speakers: 35 min (25+10)
young scientists: 25 min (15+10)

Monday, 23 November 2020

09:45   Welcome
Rainer Engers (Düsseldorf, Germany) on behalf of the AEK
Lisa Wiesmüller (Ulm, Germany)
Session 1: Replication stress in the hematopoietic system
(Chair: Lisa Wiesmüller, Ulm, Germany)
10:00 – 10.35   Michael Milyavsky (Tel Aviv, Israel):
Regulation of DNA damage response in normal and malignant hematopoietic stem cells
10:35 – 11.00   Susanne Lux (Heidelberg, Germany - PhD):
Genetic rescue of Fanca-/- HSPCs with EVI-1 overexpression suggests a mechanistic link with DNA damage response
Session 2: Non-canonical roles of p53 and MDM2
(Chair: Vanesa Gottifredi, Buenos Aires, Argentina)
11:00 – 11:35   Lisa Wiesmüller (Ulm, Germany):
The tip of an iceberg: replication-associated functions of the tumor suppressor p53
Stephanie Biber (Ulm, Germany - PhD):
Multiple biochemical properties of the p53 molecule contribute to activation of POLi -dependent DNA damage tolerance
11:35 – 12:00   Michaela Ihle (Ulm, Germany):
Impact of the interplay between stemness features, p53 and POLi on replication pathway choices
12:00 – 12:25   Matthias Dobbelstein (Göttingen, Germany):
The interplay of p53 and Mdm2 in the context of DNA replication
12:25 – 13:00   Celeste Giansanti & Valentina Manzini (Göttingen, Germany):
MDM2 promotes restart of reversed replication forks by interacting with PARP1
13:00 – 14:00   Lunch
Session 3: Crosstalk between DNA repair, replication and transcription
(Chair: Lisa Wiesmüller, Ulm, Germany)
14:00 – 14:35   Alex Sartori (Zürich, Switzerland):
Distinct roles of CtIP in repairing DNA double strand breaks and limiting replication stress
14:35 – 15:10   Joanna Morris (Birmingham, United Kingdom):
Chromatin ubiquitination supports FEN1-WRN alleviation of replication stress
15:10 – 15:35   Franziska Gehringer (Ulm, Germany - PhD):
FOXO3 expression is essential for the survival of Burkitt Lymphoma
15:35 – 16:00   Sonja Krausert (Heidelberg, Germany):
Targeting replication stress in pediatric brain tumors
16:00 – 16:25   Isabelle Röschert (Würzburg, Germany):
Aurora-A suppresses transcription-replication conflicts in MYCN-driven neuroblastoma
16:25 – 17:00   Philippe Pasero (Montpellier, France):
Causes and consequences of endogenous replication stress

Tuesday, 24 November 2020

Session 4: Safeguarding the fork and adaptation
(Chair: Matthias Dobbelstein, Göttingen, Germany)
09:00 – 09:35   Helmut Pospiech (Jena, Germany):
Fifty shades of replication stress
09.35 – 10.00   Gleice Borges (Jena, Germany):
Role of RAD18 in replication stress adaptation and tissue homeostasis
10:00 – 10:35   Claus Sørensen (Copenhagen, Denmark):
Pathways ensuring faultless cell proliferation: Uncovering new tumor suppressors
10.35 – 11.00   Sandra Classen (Hamburg, Germany):
The adaptive resistome in triple-negative breast cancer: functional targeting in patient-derived organoids and cell lines
11.00 – 11.25   Akram Hamidi (Essen, Germany - PhD):
Analysis of growth and radiation sensitivity of HIF-1A deficient cultured murine hepatocytes
Session 5: Underreplicated DNA
(Chair: Claus Sørensen, Copenhagen, Denmark)
11.25 – 12.00   Vanesa Gottifredi (Buenos Aires, Argentina):
Chromosome instability: an enemy or an ally against cancer?
12.00 – 12.25   Nicolás Calzetta (Buenos Aires, Argentina):
Molecular bases of the genomic instability triggered by incomplete MIDAS in Chk1 deficient backgrounds
12.25 – 12.50   Audrey Lumeau (Toulouse, France):
A new role for cytidine deaminase in the control of DNA replication and genome stability in pancreatic cancer cells
12.50 – 13.15   Kanstantsin Siniuk (Jena, Germany - PhD):
Poly(ADP-ribose) regulation of Chk1 in cell cycle control and cancer therapy
13:15 – 14:00   Lunch
Session 6: Helicases
(Chair: Helmut Pospiech, Jena, Germany)
14:00 – 14:35   Francesca Pisani (Naples, Italy):
Exploring the role of DDX11 and FANCJ DNA helicases in counteracting replication stress
14.35 – 15.00   Sara Egea-Rodriguez (Essen, Germany):
Role of DNA helicases in survival and progression of cancer patients – a bioinformatics analysis
Session 7: Strategies to overcome resistance
(Chair: Helmut Pospiech, Jena, Germany)
15.00 – 15.25   Julia Mann (Düsseldorf, Germany):
Targeting mechanisms of the DNA damage response to overcome cisplatin resistance
15.25 – 15.50   Natalie Bublitz (Berlin, Germany):
Modeling vulnerability of KRAS and BRAF mutant colorectal cancer towards interference with DNA damage response
15.50 – 16.15   Linda van Bijsterveldt (Oxford, United Kingdom):
Regulation of E2F target gene expression in the replication stress response
16.15 – 16.50   Eric J Brown (Philadelphia, USA):
Genomic potholes in the road to replication
16:50   Award Ceremony & Farewell